Epilepsia — Síndrome de Dravet

termo de indexação original: Epilepsy - Dravet Syndrome

O acervo do Cannabis Indica reúne 143 estudos científicos que tocam a condição Epilepsia — Síndrome de Dravet, publicados entre 1893 e 2024. Pela leitura automatizada, 120 (84%) foram classificados como favoráveis, 15 (10%) como inconclusivos e 8 (6%) como desfavoráveis — uma leitura de máquina, feita para navegar, não para concluir. O desenho mais frequente é metanálise (73 estudos), seguido de ensaio clínico (23). Os compostos mais presentes são CBD Farmacêutico, Tetraidrocanabinol (THC) e THC Farmacêutico. Aparece com frequência ao lado de Epilepsia, Epilepsia — Lennox-Gastaut e Dor.

Estudos indexados: 143
Período coberto: 1893–2024
Favoráveis: 120 · 84%
Inconclusivos: 15 · 10%
Desfavoráveis: 8 · 6%
Termo original: Epilepsy - Dravet Syndrome

O acervo em números

Tipo de estudo

Metanálise73

Ensaio Clínico23

Metanálise Clínica19

Estudo em Animais11

Ensaio Clínico Duplo-Cego9

Estudo Laboratorial8

Direção do resultado

Favorável120

Inconclusivo15

Desfavorável8

Por década

1890s1

1940s1

1980s1

2010s51

2020s89

Aparece junto com

Epilepsia142 Epilepsia — Lennox-Gastaut104 Dor20 Câncer17 Ansiedade17 Inflamação16 Dor — Crônica12 Náusea e Vômito12

143 estudos

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2024
Dravet syndrome seizure frequency and clustering: Placebo-treated patients in clinical trials
FavorávelMetanálise ClínicaEpilepsia
2024
Placebo response in patients with Dravet syndrome: Post-hoc analysis of two clinical trials
InconclusivoMetanálise ClínicaEpilepsia
2024
The efficacy and safety of cannabidiol (CBD) in pediatric patients with Dravet Syndrome: a narrative review of clinical trials
FavorávelMetanálise ClínicaEpilepsia CBD Farmacêutico
2023
A Rare Case of Cannabinoid Hyperemesis Syndrome Secondary to Cannabidiol for Refractory Epilepsy
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Epilepsia Náusea e Vômito+3
2023
Biotechnological Fungal Platforms for the Production of Biosynthetic Cannabinoids
FavorávelEstudo LaboratorialDor Câncer Inflamação Tetraidrocanabinol (THC)THC Farmacêutico+25
2023
Cannabidiol as an Adjunct to Botulinum Toxin in Blepharospasm - A Randomized Pilot Study
FavorávelEnsaio Clínico Duplo-CegoDor Câncer Dor — Crônica THC Farmacêutico THC:CBD Farmacêutico+8
2023
Cannabidiol: Bridge between Antioxidant Effect, Cellular Protection, and Cognitive and Physical Performance
FavorávelMetanáliseDor Inflamação Ansiedade Anandamida (AEA)Endocanabinoide (não especificado)+23
2023
Clinical efficacy and safety of cannabidiol for pediatric refractory epilepsy indications: A systematic review and meta-analysis
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2023
Could cannabinoids provide a new hope for ovarian cancer patients?
FavorávelMetanáliseDor Câncer Inflamação Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+24
2023
Effects of Cannabidiol on Innate Immunity: Experimental Evidence and Clinical Relevance
FavorávelMetanáliseCâncer Inflamação Ansiedade Canabigerol (CBG)Canabinol (CBN)+20
2023
Establishment of a point of departure for CBD hepatotoxicity employing human HepaRG spheroids
InconclusivoEstudo LaboratorialCâncer Inflamação Epilepsia Tetraidrocanabinol (THC)CBD Farmacêutico+3
2023
Fenfluramine for Treating Dravet Syndrome: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
FavorávelMetanáliseEpilepsia Qualidade de Vida
2023
Medical Cannabis Received by Patients According to Qualifying Condition in a US State Cannabis Program: Product Choice, Dosing, and Age-Related Trends
FavorávelMetanáliseDor Câncer Dor — Crônica THC Farmacêutico CBD Farmacêutico+16
2023
Pharmacotherapy for Dravet Syndrome: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
FavorávelMetanálise ClínicaEpilepsia CBD Farmacêutico
2023
Use of non-medical cannabis in epilepsy: A scoping review
InconclusivoMetanáliseEpilepsia Esclerose Múltipla Doença de Alzheimer CBD Farmacêutico+2
2022
A Practical Guide to the Treatment of Dravet Syndrome with Anti-Seizure Medication
FavorávelMetanáliseEpilepsia Disfunção Cognitiva CBD Farmacêutico
2022
A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment
FavorávelMetanáliseDor Câncer Ansiedade Anandamida (AEA)Tetraidrocanabinol (THC)+25
2022
Adjunctive Transdermal Cannabidiol for Adults With Focal Epilepsy: A Randomized Clinical Trial
InconclusivoEnsaio Clínico Duplo-CegoEpilepsia Epilepsia — Lennox-Gastaut
2022
Biochemical aspects and therapeutic mechanisms of cannabidiol in epilepsy
FavorávelMetanáliseEpilepsia Doenças Neurodegenerativas Epilepsia — Lennox-Gastaut
2022
Cannabidiol in canine epilepsy
InconclusivoMetanáliseDor Câncer Inflamação Ácido Canabidiólico (CBD-a)+7
2022
Cannabinoids in rheumatology: Friend, foe or a bystander?
InconclusivoMetanáliseDor Dor — Crônica Epilepsia Anandamida (AEA)Tetraidrocanabinol (THC)+19
2022
Cannabinoids: Therapeutic Use in Clinical Practice
FavorávelMetanálise ClínicaCâncer Epilepsia Doenças Neurodegenerativas Anandamida (AEA)Tetraidrocanabinol (THC)+16
2022
Cannabis Use in Autism: Reasons for Concern about Risk for Psychosis
InconclusivoMetanáliseEpilepsia Psicose Esquizofrenia Tetraidrocanabinol (THC)Endocanabinoide (não especificado)+2
2022
Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review
FavorávelMetanáliseDor Câncer Inflamação Anandamida (AEA)Tetraidrocanabinol (THC)+28
2022
Effects of Cannabidiol on Appetite and Body Weight: A Systematic Review
FavorávelMetanáliseAnsiedade Epilepsia Obesidade Tetraidrocanabinol (THC)+5
2022
Effects of short-term environmental stresses on the onset of cannabinoid production in young immature flowers of industrial hemp (Cannabis sativa L.)
FavorávelEstudo LaboratorialCâncer Epilepsia Doença de Parkinson Canabigerol (CBG)Canabinol (CBN)+4
2022
Efficacy and safety of adjunctive antiseizure medications for dravet syndrome: A systematic review and network meta-analysis
FavorávelMetanálise ClínicaEpilepsia
2022
Efficiency of Inhaled Cannabidiol in Cannabis Use Disorder: The Pilot Study Cannavap
FavorávelMetanáliseDependência Química Câncer Inflamação THC Farmacêutico THC:CBD Farmacêutico+11
2022
Endothelial dysfunction and angiogenesis: what is missing from COVID-19 and cannabidiol story?
FavorávelMetanáliseInflamação Epilepsia Esclerose Múltipla Tetraidrocanabinol (THC)Endocanabinoide (não especificado)+7
2022
Epilepsy and cannabis: so near, yet so far
DesfavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2022
Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications
FavorávelMetanálise ClínicaDependência — Cannabis Ansiedade Depressão Tetraidrocanabinol (THC)THC Farmacêutico+17
2022
Movement Disorders Secondary to Novel Antiseizure Medications in Pediatric Populations: A Systematic Review and Meta-analysis of Risk
InconclusivoMetanálise ClínicaEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2022
Olivetolic acid, a cannabinoid precursor in Cannabis sativa, but not CBGA methyl ester exhibits a modest anticonvulsant effect in a mouse model of Dravet syndrome
FavorávelEstudo em AnimaisEpilepsia Ácido Canabigerólico (CBG-a)
2022
Persistent Diarrhea and Eosinophilic Esophagitis Resulting From Chronic Cannabidiol Usage for Refractory Epilepsy
DesfavorávelMetanáliseDor Epilepsia DII — Doença Inflamatória Intestinal+3
2022
Practical Considerations for the Use of Cannabis in Cancer Pain Management—What a Medical Oncologist Should Know
FavorávelMetanáliseDor Câncer Epilepsia Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+14
2022
Safety, Pharmacokinetics and Pharmacodynamics of Spectrum Yellow Oil in Healthy Participants
FavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Epilepsia — Lennox-Gastaut Perda de Apetite Tetraidrocanabinol (THC)THC:CBD Farmacêutico+2
2022
TRPV1: A Common Denominator Mediating Antinociceptive and Antiemetic Effects of Cannabinoids
FavorávelMetanáliseDor Inflamação Efeitos Adversos da Cannabis Anandamida (AEA)Endocanabinoide (não especificado)+18
2022
Use of cannabidiol in the treatment of epilepsy: Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Add-on cannabidiol in patients with Dravet syndrome: Results of a long-term open-label extension trial
FavorávelEnsaio ClínicoEpilepsia
2021
An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models
InconclusivoEstudo LaboratorialEpilepsia Epilepsia — Lennox-Gastaut 2-Araquidonoilglicerol (2-AG)Canabicromeno (CBC)+2
2021
Cannabichromene, Related Phytocannabinoids, and 5-Fluoro-cannabichromene Have Anticonvulsant Properties in a Mouse Model of Dravet Syndrome
FavorávelEstudo em AnimaisEpilepsia Canabicromeno (CBC)Ácido Canabicromênico (CBC-a)
2021
Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial
FavorávelMetanáliseEfeitos Adversos da Cannabis Epilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico+1
2021
Cannabidiol and mental health: possibilities, uncertainties, and controversies for addiction treatment
InconclusivoMetanáliseDependência Química Ansiedade Depressão+10
2021
Cannabidiol and Neurodevelopmental Disorders in Children
FavorávelMetanáliseInflamação Ansiedade Depressão Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+17
2021
Cannabidiol and Sodium Channel Pharmacology: General Overview, Mechanism, and Clinical Implications
FavorávelMetanáliseEpilepsia
2021
Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2021
Cannabidiol in Pharmacoresistant Epilepsy: Clinical Pharmacokinetic Data From an Expanded Access Program
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Cannabidiol in the Treatment of Epilepsy
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review
DesfavorávelMetanáliseDepressão Epilepsia Dependência — Opioides CBD Farmacêutico+3
2021
Cannabidiol treatment of severe refractory epilepsy in children and young adults
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2021
Cannabidiol: pharmacology and therapeutic targets
FavorávelMetanáliseDor Inflamação Dor — Crônica+4
2021
Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy
FavorávelEstudo em AnimaisEpilepsia Ácido Canabigerólico (CBG-a)
2021
Case Report: Lennox-Gastaut Epileptic Encephalopathy Responsive to Cannabidiol Treatment Associated With a Novel de novo Mosaic SHANK1 Variant
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut Autismo
2021
Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome
FavorávelEstudo em AnimaisEpilepsia
2021
Cost-Effectiveness of Medicinal Cannabis for Management of Refractory Symptoms Associated With Chronic Conditions: A Systematic Review of Economic Evaluations
FavorávelMetanáliseDor Dor — Crônica Epilepsia THC Farmacêutico THC:CBD Farmacêutico+7
2021
Cytochrome P450-Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol
DesfavorávelEstudo LaboratorialEpilepsia Epilepsia — Lennox-Gastaut Hepatite CBD Farmacêutico+1
2021
Dravet syndrome
FavorávelMetanáliseEpilepsia
2021
Effect of Cannabidiol on Interictal Epileptiform Activity and Sleep Architecture in Children with Intractable Epilepsy: A Prospective Open-Label Study
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Efficacy and safety of medical cannabinoids in children: a systematic review and meta-analysis
FavorávelMetanáliseEfeitos Adversos da Cannabis Epilepsia Perda de Apetite THC Farmacêutico THC:CBD Farmacêutico+2
2021
Efficacy and safety of paediatric medicinal cannabis use: A scoping review
DesfavorávelMetanáliseDor Câncer Epilepsia THC Farmacêutico CBD Farmacêutico+6
2021
Epileptic Phenotype and Cannabidiol Efficacy in a Williams–Beuren Syndrome Patient With Atypical Deletion: A Case Report
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Highly Purified Cannabidiol for Epilepsy Treatment: A Systematic Review of Epileptic Conditions Beyond Dravet Syndrome and Lennox-Gastaut Syndrome
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Lennox-Gastaut
2021
Improved Bioavailability with Dry Powder Cannabidiol Inhalation: A Phase 1 Clinical Study
FavorávelEnsaio ClínicoDor Ansiedade Dor — Crônica CBD Farmacêutico+3
2021
Long-term cannabidiol treatment for seizures in patients with tuberous sclerosis complex: An open-label extension trial
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Natural and Synthetic Cannabinoids: Pharmacology, Uses, Adverse Drug Events, and Drug Interactions
DesfavorávelMetanáliseDor Dependência Química Efeitos Adversos da Cannabis 2-Araquidonoilglicerol (2-AG)Canabinoide Sintético (não especificado)+24
2021
New therapeutic approach in Dravet syndrome and Lennox-Gastaut syndrome with cannabidiol
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Perspectives of pediatric oncologists and palliative care physicians on the therapeutic use of cannabis in children with cancer
FavorávelMetanáliseDor Câncer Dor — Crônica+7
2021
Preclinical investigation of β-caryophyllene as a therapeutic agent in an experimental murine model of Dravet syndrome
FavorávelEstudo em AnimaisEpilepsia
2021
Results From an Italian Expanded Access Program on Cannabidiol Treatment in Highly Refractory Dravet Syndrome and Lennox–Gastaut Syndrome
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Time to onset of cannabidiol treatment effects in Dravet syndrome: Analysis from two randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2021
Treatment Guidelines for Rare, Early-Onset, Treatment-Resistant Epileptic Conditions: A Literature Review on Dravet Syndrome, Lennox-Gastaut Syndrome and CDKL5 Deficiency Disorder
InconclusivoMetanálise ClínicaEpilepsia Epilepsia — Lennox-Gastaut
2021
Two-center experience of cannabidiol use in adults with Dravet syndrome
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut Qualidade de Vida CBD Farmacêutico
2020
A Phase 2, Double-Blind, Placebo-Controlled Trial to Investigate Potential Drug-Drug Interactions Between Cannabidiol and Clobazam
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
A Phase I, Open-Label, Parallel-Group, Single-Dose Trial of the Pharmacokinetics, Safety, and Tolerability of Cannabidiol in Subjects with Mild to Severe Renal Impairment
FavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Epilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico+1
2020
A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Adjunctive Cannabidiol in Patients with Dravet Syndrome: A Systematic Review and Meta-Analysis of Efficacy and Safety
FavorávelMetanálise ClínicaEpilepsia
2020
Cannabidiol (CBD)
FavorávelMetanáliseInflamação Ansiedade Epilepsia+4
2020
Cannabidiol efficacy independent of clobazam: Meta-analysis of four randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Cannabidiol for epilepsy (Lennox-Gastaut syndrome, Dravet syndrome)
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Clinical trial simulations of the interaction between cannabidiol and clobazam and effect on drop-seizure frequency
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2020
Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Dose-Ranging Effect of Adjunctive Oral Cannabidiol vs Placebo on Convulsive Seizure Frequency in Dravet Syndrome: A Randomized Clinical Trial
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Drug-Drug Interactions Between Cannabidiol and Lithium
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut Autismo+1
2020
Economic Evaluation of Cannabinoid Oil for Dravet Syndrome: A Cost-Utility Analysis
FavorávelMetanáliseEpilepsia
2020
Effect of Cannabinoids on Electroencephalography of a Child with Lennox-Gastaut Syndrome
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Interactions between cannabidiol and Δ 9 -tetrahydrocannabinol in modulating seizure susceptibility and survival in a mouse model of Dravet syndrome
FavorávelEstudo em AnimaisEpilepsia
2020
Pharmacogenetic Predictors of Cannabidiol Response and Tolerability in Treatment-Resistant Epilepsy
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2020
Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model
FavorávelEstudo em AnimaisEpilepsia Canabinoides Sintéticos JWH-x Canabinoides Sintéticos AB-x
2020
Practical use of pharmaceutically purified oral cannabidiol in Dravet syndrome and Lennox-Gastaut syndrome
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
A Phase 1, Open-Label, Pharmacokinetic Trial to Investigate Possible Drug-Drug Interactions Between Clobazam, Stiripentol, or Valproate and Cannabidiol in Healthy Subjects
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2019
A systematic review of cannabidiol dosing in clinical populations
FavorávelMetanálise ClínicaDor Dependência — Cannabis Ansiedade+14
2019
Are there mortality risks for patients with epilepsy who use cannabis treatments as monotherapy?
DesfavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Can we teach old drugs new tricks?-Repurposing of neuropharmacological drugs for inflammatory skin diseases
FavorávelMetanáliseInflamação Depressão Epilepsia+14
2019
Cannabidiol as adjunctive treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome
InconclusivoMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2019
Cannabidiol: A New Hope for Patients With Dravet or Lennox-Gastaut Syndromes
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Cannabidiol: A Review of Clinical Efficacy and Safety in Epilepsy
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Cannabinoid therapy in epilepsy
InconclusivoMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Cannabis and Epilepsy
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Cannabis for refractory epilepsy in children: A review focusing on CDKL5 Deficiency Disorder
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Cannabis-based products for pediatric epilepsy: A systematic review
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Cannabis-based treatments as an alternative remedy for epilepsy
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions
FavorávelEstudo em AnimaisEpilepsia Epilepsia — Lennox-Gastaut
2019
Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy
InconclusivoMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Dosage Related Efficacy and Tolerability of Cannabidiol in Children With Treatment-Resistant Epileptic Encephalopathy: Preliminary Results of the CARE-E Study
FavorávelEnsaio ClínicoEpilepsia Canabicromeno (CBC)
2019
Effects of cannabidiol (CBD) in neuropsychiatric disorders: A review of pre-clinical and clinical findings
FavorávelMetanáliseAnsiedade Epilepsia Psicose+3
2019
Efficacy of cannabinoids in paediatric epilepsy
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Long-term cannabidiol treatment in patients with Dravet syndrome: An open-label extension trial
FavorávelEnsaio ClínicoEpilepsia Perda de Apetite Diarreia CBD Farmacêutico+1
2019
Long-term safety and efficacy of cannabidiol in children and adults with treatment resistant Lennox-Gastaut syndrome or Dravet syndrome: Expanded access program results
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut Diarreia CBD Farmacêutico
2019
Pharmacokinetics and Tolerability of Multiple Doses of Pharmaceutical-Grade Synthetic Cannabidiol in Pediatric Patients with Treatment-Resistant Epilepsy
InconclusivoEnsaio ClínicoEfeitos Adversos da Cannabis Epilepsia Epilepsia — Lennox-Gastaut
2019
Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid in a Mouse Model of Dravet Syndrome
FavorávelEstudo em AnimaisEpilepsia Ácido Canabidiólico (CBD-a)
2019
Pharmacological and Therapeutic Properties of Cannabidiol for Epilepsy
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
Plants come to mind: phytocannabinoids, endocannabinoids and the control of seizures
FavorávelMetanáliseEpilepsia Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+1
2019
Purified Cannabidiol for Treatment of Refractory Epilepsies in Pediatric Patients with Developmental and Epileptic Encephalopathy
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut
2019
Safety, efficacy, and mechanisms of action of cannabinoids in neurological disorders
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2019
The safety, tolerability, and effectiveness of PTL-101, an oral cannabidiol formulation, in pediatric intractable epilepsy: A phase II, open-label, single-center study
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut
2019
Treatment of Seizures Associated with Lennox-Gastaut and Dravet Syndromes: A Focus on Cannabidiol Oral Solution
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2018
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut Tetraidrocanabinol (THC)CBD Farmacêutico
2018
A prospective open-label trial of a CBD/THC cannabis oil in Dravet Syndrome.
FavorávelEnsaio ClínicoEpilepsia Qualidade de Vida Tetraidrocanabinol (THC)
2018
Abuse potential assessment of cannabidiol (CBD) in recreational polydrug users: A randomized, double-blind, controlled trial
FavorávelEnsaio Clínico Duplo-CegoEfeitos Adversos da Cannabis Epilepsia Disfunção Cognitiva THC Farmacêutico CBD Farmacêutico+5
2018
Cannabidiol for drug-resistant seizures in the Dravet syndrome
FavorávelEnsaio ClínicoEpilepsia Náusea e Vômito Anorexia (perda de apetite)+1
2018
Cannabis for paediatric epilepsy: challenges and conundrums
FavorávelMetanáliseEpilepsia
2018
Cannabis for the Treatment of Epilepsy: an Update
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2018
Cannabis Therapeutics and the Future of Neurology
FavorávelMetanáliseCâncer Epilepsia Doenças Neurodegenerativas Tetraidrocanabinol (THC)Ácido Canabidiólico (CBD-a)+8
2018
Efficacy and Safety of Cannabidiol in Epilepsy: A Systematic Review and Meta-Analysis
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2018
Investigating the Therapeutic Mechanism of Cannabidiol in a Human Induced Pluripotent Stem Cell (iPSC)-Based Model of Dravet Syndrome
FavorávelEstudo LaboratorialEpilepsia
2018
Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2018
Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Náusea e Vômito Perda de Apetite
2017
Cannabidiol Attenuates Seizures And Social Deficits In A Mouse Model Of Dravet Syndrome
FavorávelEstudo em AnimaisEpilepsia Autismo
2017
Cannabinoids in treatment-resistant epilepsy: A review.
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
2017
Neurological Aspects Of Medical Use Of Cannabidiol
FavorávelMetanáliseEpilepsia Disfunção Cognitiva Esclerose Múltipla+4
2017
Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
FavorávelEnsaio Clínico Duplo-CegoEpilepsia Náusea e Vômito Diarreia CBD Farmacêutico
2016
A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs)
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut Epilepsia — FIRES Anandamida (AEA)Proteína Ligadora de Ácidos Graxos (FABP)
2016
Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol.
FavorávelEstudo LaboratorialEpilepsia
2016
Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome.
FavorávelEstudo LaboratorialEpilepsia 2-Araquidonoilglicerol (2-AG)Monoacilglicerol Lipase (MAGL)+1
2016
Oral cannabidiol does not produce a signal for abuse liability in frequent marijuana smokers
FavorávelEnsaio ClínicoDor Dependência Química Câncer Anandamida (AEA)Hidrolase de Amidas de Ácidos Graxos (FAAH)+13
2014
Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.
FavorávelMetanáliseInflamação Dependência — Cannabis Ansiedade Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+17
2014
Efficacy and Safety of Epidiolex (Cannabidiol) in Children and Young Adults with Treatment-Resistant Epilepsy: Initial Data From an Expanded Access Program.
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut CBD Farmacêutico
2014
Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se.
FavorávelEstudo em AnimaisEpilepsia Canabigerol (CBG)
2013
Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy.
FavorávelMetanáliseEpilepsia Epilepsia — Lennox-Gastaut
1981
Hypnotic And Antiepileptic Effects Of Cannabidiol
FavorávelMetanálise ClínicaEpilepsia Insônia e Distúrbios do Sono Epilepsia — Lennox-Gastaut
1949
Anti-epileptic Action of Marijuana-Active Subtances
FavorávelEnsaio ClínicoEpilepsia Epilepsia — Lennox-Gastaut Paralisia Cerebral Tetraidrocanabinol (THC)Canabinol (CBN)
1893
Report of the Indian Hemp Drugs Commission, 1893-1894 (Volume 1)
FavorávelMetanáliseEfeitos Adversos da Cannabis Ansiedade Doenças Cardiovasculares (DCV)+16

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Canabinoides e compostos

CBD Farmacêutico 55 Tetraidrocanabinol (THC) 15 THC Farmacêutico 15 THC:CBD Farmacêutico 15 Anandamida (AEA) 13 2-Araquidonoilglicerol (2-AG) 11 Hidrolase de Amidas de Ácidos Graxos (FAAH) 11 Canabicromeno (CBC) 9

Sistemas do corpo

Sistema Nervoso 79 Saúde Mental e Emocional 9 Sistema Digestório 4 Pele e Anexos 2 Sistema Reprodutor 1 Sistema Respiratório 1

Perguntas frequentes

Quantos estudos sobre epilepsia — síndrome de dravet estão indexados no acervo?

São 143 estudos, publicados entre 1893 e 2024. O acervo inteiro tem 7.640 registros.

Que tipos de estudo predominam?

Metanálise: 73 · Ensaio Clínico: 23 · Metanálise Clínica: 19 · Estudo em Animais: 11 · Ensaio Clínico Duplo-Cego: 9 · Estudo Laboratorial: 8. A classificação segue o desenho declarado na fonte.

O que significa a classificação de resultado?

É uma leitura automatizada da conclusão de cada estudo, em três direções — favorável, inconclusivo e desfavorável. Aqui são 120 favoráveis, 15 inconclusivos e 8 desfavoráveis. Serve para navegar o acervo, não para concluir nada clinicamente: a conclusão válida é a do artigo original.

Como citar esta página

ABNT

CANNABIS INDICA. Epilepsia — Síndrome de Dravet — estudos científicos sobre cannabis. 2026. Disponível em: https://cannabisindica.com.br/condicao/epilepsia-sindrome-de-dravet/. Acesso em: 13 set. 2026.

APA

Cannabis Indica. (2026). Epilepsia — Síndrome de Dravet — estudos científicos sobre cannabis. https://cannabisindica.com.br/condicao/epilepsia-sindrome-de-dravet/

Esta página é um índice de acesso. Ao usar um estudo como evidência, cite o artigo original — o link de cada registro leva à fonte.