Insônia e Distúrbios do Sono

termo de indexação original: Insomnia and Sleep Disorders

O acervo do Cannabis Indica reúne 296 estudos científicos que tocam a condição Insônia e Distúrbios do Sono, publicados entre 1839 e 2024. Pela leitura automatizada, 216 (73%) foram classificados como favoráveis, 46 (16%) como inconclusivos e 34 (11%) como desfavoráveis — uma leitura de máquina, feita para navegar, não para concluir. O desenho mais frequente é metanálise (147 estudos), seguido de ensaio clínico (46). Os compostos mais presentes são Tetraidrocanabinol (THC), THC Farmacêutico e THC:CBD Farmacêutico. Aparece com frequência ao lado de Ansiedade, Dor e Depressão.

Estudos indexados: 296
Período coberto: 1839–2024
Favoráveis: 216 · 73%
Inconclusivos: 46 · 16%
Desfavoráveis: 34 · 11%
Termo original: Insomnia and Sleep Disorders

O acervo em números

Tipo de estudo

Metanálise147

Ensaio Clínico46

Ensaio Clínico Duplo-Cego45

Metanálise Clínica29

Estudo em Animais24

Estudo Laboratorial5

Direção do resultado

Favorável216

Inconclusivo46

Desfavorável34

Por década

1830s1

1840s1

1890s1

1910s1

1970s6

1980s2

1990s1

2000s10

2010s69

2020s204

Aparece junto com

Ansiedade130 Dor123 Depressão82 Dor — Crônica70 Efeitos Adversos da Cannabis46 Câncer41 Dependência — Cannabis38 Epilepsia38

296 estudos

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2024
An intervention based on Well-Being Therapy to prevent alcohol use and other unhealthy lifestyle behaviors among students: a three-arm cluster randomized controlled trial
FavorávelEnsaio ClínicoDependência Química Efeitos Adversos da Cannabis Dependência — Cannabis Exercício Físico Dieta+4
2024
Assessment of Clinical Outcomes in Patients With Osteoarthritis: Analysis From the UK Medical Cannabis Registry
FavorávelMetanáliseDor Ansiedade Artrite THC Farmacêutico THC:CBD Farmacêutico+1
2024
Cannabidiol for moderate-severe insomnia: a randomized controlled pilot trial of 150 mg of nightly dosing
InconclusivoEnsaio ClínicoCanabidiol (CBD)
2024
Cannabidiol Intervention for Muscular Tension, Pain, and Sleep Bruxism Intensity-A Randomized, Double-Blind Clinical Trial
FavorávelEnsaio Clínico Duplo-CegoDor Disfunção Temporomandibular (DTM)CBD Farmacêutico
2024
Evaluating possible 'next day' impairment in insomnia patients administered an oral medicinal cannabis product by night: a pilot randomized controlled trial
InconclusivoEnsaio ClínicoEfeitos Adversos da Cannabis Disfunção Cognitiva
2024
Evaluating the Impact of Probiotic Therapy on the Endocannabinoid System, Pain, Sleep and Fatigue: A Randomized, Double-Blind, Placebo-Controlled Trial in Dancers
FavorávelEnsaio Clínico Duplo-CegoDor Endocanabinoide (não especificado)Proteína Ligadora de Ácidos Graxos (FABP)+3
2024
Evaluation of the efficacy, safety, and pharmacokinetics of nanodispersible cannabidiol oral solution (150 mg/mL) versus placebo in mild to moderate anxiety subjects: A double blind multicenter randomized clinical trial
FavorávelEnsaio Clínico Duplo-CegoAnsiedade Depressão TEPT+2
2024
Short-Term Cannabidiol with Δ-9-Tetrahydrocannabinol in Parkinson's Disease: A Randomized Trial
DesfavorávelEnsaio Clínico Duplo-CegoEfeitos Adversos da Cannabis Disfunção Cognitiva Doenças Neurodegenerativas+1
2024
Sleep quality of adult recreational cannabis users: a systematic review of literature
DesfavorávelMetanálise ClínicaEfeitos Adversos da Cannabis
2024
The Effect of Palmitoylethanolamide (PEA) on Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training in Healthy Active Adults: A Double-Blind Randomized Control Trial
FavorávelEnsaio Clínico Duplo-CegoDor Qualidade de Vida Palmitoiletanolamida (PEA)
2024
The Interplay of Sleep Quality, Mental Health, and Sociodemographic and Clinical Factors among Italian College Freshmen
DesfavorávelEnsaio ClínicoDependência Química Ansiedade Depressão+2
2024
Δ9-Tetrahydrocannabinol (THC): A Critical Overview of Recent Clinical Trials and Suggested Guidelines for Future Research
FavorávelMetanálise ClínicaDor Dependência Química Dependência — Cannabis Tetraidrocanabinol (THC)THC Farmacêutico+13
2023
A double-blind, randomized, placebo-controlled study of the safety and effects of CBN with and without CBD on sleep quality
FavorávelEnsaio Clínico Duplo-CegoCanabinol (CBN)
2023
A Randomized, Double-Blind, Placebo-Controlled Decentralized Trial to Assess Sleep, Health Outcomes, and Overall Well-Being in Healthy Adults Reporting Disturbed Sleep, Taking a Melatonin-Free Supplement
FavorávelEnsaio ClínicoDor Ansiedade Tetraidrocanabinol (THC)Canabinol (CBN)
2023
A systematic review and meta-analysis of the association between young adults' sleep habits and substance use, with a focus on self-medication behaviours
DesfavorávelMetanáliseDependência Química Dependência — Cannabis Dependência — Álcool+1
2023
Alleviation of Pain, PAIN Interference, and Oxidative Stress by a Novel Combination of Hemp Oil, Calamari Oil, and Broccoli: A Randomized, Double-Blind, Placebo-Controlled Trial
FavorávelEnsaio Clínico Duplo-CegoDor Dependência Química Inflamação Ômega-3+2
2023
An observational study of clinical outcome measures in patients treated with cannabis-based medicinal products on the UK Medical Cannabis Registry
FavorávelMetanáliseDependência Química Ansiedade Dependência — Opioides+1
2023
An observational study of safety and clinical outcome measures across patient groups in the United Kingdom Medical Cannabis Registry
FavorávelMetanáliseDor Ansiedade Depressão+1
2023
Assessing changes in sleep across four weeks among adolescents randomized to incentivized cannabis abstinence
DesfavorávelEnsaio ClínicoDependência Química Dependência — Cannabis
2023
Biotechnological Fungal Platforms for the Production of Biosynthetic Cannabinoids
FavorávelEstudo LaboratorialDor Câncer Inflamação Tetraidrocanabinol (THC)THC Farmacêutico+25
2023
Buprenorphine versus methadone for the treatment of opioid dependence: a systematic review and meta-analysis of randomised and observational studies
FavorávelMetanáliseDor Dependência Química Dependência — Opioides+3
2023
Cannabidiol safety considerations: Development of a potential acceptable daily intake value and recommended upper intake limits for dietary supplement use
FavorávelEnsaio ClínicoDor Câncer Efeitos Adversos da Cannabis Tetraidrocanabinol (THC)THC:CBD Farmacêutico+10
2023
Cannabinoids versus placebo for pain: A systematic review with meta-analysis and Trial Sequential Analysis
InconclusivoMetanálise ClínicaDor Dependência Química Câncer+15
2023
Cannabis use and sleep quality in daily life: An electronic daily diary study of adults starting cannabis for health concerns
FavorávelEnsaio ClínicoDor Depressão
2023
Cannabis use for exercise recovery in trained individuals: a survey study
FavorávelMetanáliseDor Inflamação Efeitos Adversos da Cannabis Exercício Físico+1
2023
Cannabis use for medical symptoms: Patterns over the first year of use
FavorávelMetanáliseDor Dependência Química Dependência — Cannabis+2
2023
CBD-oil as a potential solution in case of severe tamoxifen-related side effects
FavorávelEnsaio ClínicoDor Câncer Câncer — Mama+2
2023
Cognitive behavioral therapy for insomnia to reduce cannabis use: Results from a pilot randomized controlled trial
FavorávelEnsaio ClínicoDependência Química Dependência — Cannabis
2023
Development of cannabis use disorder in medical cannabis users: A 9-month follow-up of a randomized clinical trial testing effects of medical cannabis card ownership
DesfavorávelEnsaio ClínicoDor Dependência Química Efeitos Adversos da Cannabis+3
2023
Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions
FavorávelMetanálise
2023
Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review
InconclusivoMetanáliseDor Câncer Inflamação Anandamida (AEA)Endocanabinoide (não especificado)+26
2023
Health-related quality of life in patients accessing medicinal cannabis in Australia: The QUEST initiative results of a 3-month follow-up observational study
FavorávelMetanáliseDor Ansiedade Dor — Crônica+2
2023
Induction of Anxiety-Like Phenotypes by Knockdown of Cannabinoid Type-1 Receptors in the Amygdala of Marmosets
DesfavorávelEstudo em AnimaisAnsiedade Depressão Disfunção Cognitiva Endocanabinoide (não especificado)+1
2023
Medical Cannabis Received by Patients According to Qualifying Condition in a US State Cannabis Program: Product Choice, Dosing, and Age-Related Trends
FavorávelMetanáliseDor Câncer Dor — Crônica THC Farmacêutico CBD Farmacêutico+16
2023
Multinational Association of Supportive Care in Cancer (MASCC) guidelines: cannabis for psychological symptoms including insomnia, anxiety, and depression
InconclusivoMetanálise ClínicaCâncer Ansiedade Depressão+1
2023
The Effects of Pharmacological Treatment of Nightmares: A Systematic Literature Review and Meta-Analysis of Placebo-Controlled, Randomized Clinical Trials
FavorávelMetanálise ClínicaAnsiedade Depressão TEPT Tetraidrocanabinol (THC)CBD Farmacêutico
2023
The Influence of Oral Cannabidiol on 24-h Ambulatory Blood Pressure and Arterial Stiffness in Untreated Hypertension: A Double-Blind, Placebo-Controlled, Cross-Over Pilot Study
FavorávelEnsaio Clínico Duplo-CegoDoenças Cardiovasculares (DCV)Hipertensão Arterial
2023
The Safety and Comparative Effectiveness of Non-Psychoactive Cannabinoid Formulations for the Improvement of Sleep: A Double-Blinded, Randomized Controlled Trial
FavorávelEnsaio Clínico Duplo-CegoEfeitos Adversos da Cannabis Psicose Canabinol (CBN)Canabicromeno (CBC)
2023
The safety and efficacy of low oral doses of cannabidiol: An evaluation of the evidence
FavorávelMetanálise ClínicaDor Dependência Química Ansiedade+2
2023
Use of Cannabidiol in the Management of Insomnia: A Systematic Review
FavorávelMetanálise ClínicaTetraidrocanabinol (THC)THC:CBD Farmacêutico
2022
A Coala-T-Cannabis Survey Study of breast cancer patients' use of cannabis before, during, and after treatment
FavorávelMetanáliseDor Câncer Ansiedade+5
2022
A Placebo-Controlled Trial of Cannabinoid Treatment for Disruptive Behavior in Children and Adolescents with Autism Spectrum Disorder: Effects on Sleep Parameters as Measured by the CSHQ
InconclusivoEnsaio Clínico Duplo-CegoTranstornos de Comportamento Autismo Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+1
2022
A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain
FavorávelEnsaio Clínico Duplo-CegoDor Inflamação Ansiedade Anandamida (AEA)Palmitoiletanolamida (PEA)+5
2022
A survey of medical cannabis use during perimenopause and postmenopause
InconclusivoMetanáliseAnsiedade Menopausa Sudorese Noturna e Excessiva Endocanabinoide (não especificado)
2022
Advanced in Vitro Safety Assessment of Herbal Medicines for the Treatment of Non-Psychotic Mental Disorders in Pregnancy
InconclusivoEstudo LaboratorialAnsiedade Depressão Gestação+1
2022
An investigation of cannabis use for insomnia in depression and anxiety in a naturalistic sample
FavorávelMetanáliseAnsiedade Depressão
2022
An Updated Analysis of Clinical Outcome Measures Across Patients From the UK Medical Cannabis Registry
FavorávelEnsaio ClínicoDor Efeitos Adversos da Cannabis Ansiedade+3
2022
Attention-Deficit Hyperactivity Disorder and Therapeutic Cannabis Use Motives
DesfavorávelMetanáliseDependência Química Efeitos Adversos da Cannabis Dependência — Cannabis+2
2022
Ayahuasca-Induced Psychosis: A Case Report
DesfavorávelMetanálisePsicose Ayahuasca
2022
Cannabidiol as a personalized treatment for anxiety: clinical cases in Mexico
FavorávelMetanáliseAnsiedade Depressão TEPT Anandamida (AEA)Endocanabinoide (não especificado)+6
2022
Cannabidiol for the treatment of autism spectrum disorder: hope or hype?
FavorávelMetanáliseAnsiedade Depressão Epilepsia Endocanabinoide (não especificado)+3
2022
Cannabidiol in Treatment of Autism Spectrum Disorder: A Case Study
FavorávelMetanáliseAnsiedade Depressão Epilepsia Anandamida (AEA)Tetraidrocanabinol (THC)+8
2022
Cannabinoid hyperemesis syndrome and cannabis withdrawal syndrome: a review of the management of cannabis-related syndrome in the emergency department
DesfavorávelMetanáliseInflamação Efeitos Adversos da Cannabis Dependência — Cannabis Tetraidrocanabinol (THC)THC Farmacêutico+13
2022
Cannabinoid treatments for anxiety: A systematic review and consideration of the impact of sleep disturbance
FavorávelMetanáliseAnsiedade Endocanabinoide (não especificado)
2022
Cannabinoids for Symptom Management in Patients with Kidney Failure: A Narrative Review
DesfavorávelMetanáliseDor Inflamação Ansiedade+10
2022
Cannabinoids in the management of behavioral, psychological, and motor symptoms of neurocognitive disorders: a mixed studies systematic review
FavorávelMetanáliseDisfunção Cognitiva Psicose Doença de Alzheimer Canabinoide Sintético (não especificado)THC Farmacêutico+4
2022
Cannabinoids-Perspectives for Individual Treatment in Selected Patients: Analysis of the Case Series
FavorávelMetanáliseDor Câncer Inflamação Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+13
2022
Cannabinoids, Insomnia, and Other Sleep Disorders
InconclusivoMetanáliseCanabinol (CBN)
2022
Cannabis dosing and administration for sleep: a systematic review
InconclusivoMetanálise ClínicaTetraidrocanabinol (THC)
2022
Cannabis in Palliative Care: A Systematic Review of Current Evidence
InconclusivoMetanáliseCâncer Epilepsia Náusea e Vômito+6
2022
Cannabis in Parkinson's Disease - the patient's perspective versus clinical trials: a systematic literature review
DesfavorávelMetanálise ClínicaDor Inflamação Ansiedade Anandamida (AEA)Endocanabinoide (não especificado)+5
2022
Cannabis Use and the Endocannabinoid System: A Clinical Perspective
InconclusivoMetanáliseDor Efeitos Adversos da Cannabis Dependência — Cannabis Anandamida (AEA)Tetraidrocanabinol (THC)+19
2022
Cannabis use as a moderator of cognitive behavioral therapy for insomnia
InconclusivoEnsaio Clínico Duplo-Cego
2022
Cannabis use in patients with insomnia and sleep disorders: Retrospective chart review
FavorávelMetanálise
2022
Capgras Syndrome Due to Cannabinoids Use: A Case Report With Radiological Findings
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Ansiedade Psicose+1
2022
Children and adolescents with ASD treated with CBD-rich cannabis exhibit significant improvements particularly in social symptoms: an open label study
FavorávelEnsaio ClínicoAnsiedade Transtornos de Comportamento Autismo Anandamida (AEA)Tetraidrocanabinol (THC)+3
2022
Clinical and cognitive improvement following full-spectrum, high-cannabidiol treatment for anxiety: open-label data from a two-stage, phase 2 clinical trial
FavorávelEnsaio ClínicoAnsiedade Disfunção Cognitiva Qualidade de Vida
2022
Clinical Management of Sleep and Sleep Disorders With Cannabis and Cannabinoids: Implications to Practicing Psychiatrists
FavorávelMetanáliseAnsiedade Depressão TEPT THC Farmacêutico+1
2022
Clinical outcome analysis of patients with autism spectrum disorder: analysis from the UK Medical Cannabis Registry
FavorávelMetanáliseEfeitos Adversos da Cannabis Ansiedade Depressão Anandamida (AEA)Tetraidrocanabinol (THC)+3
2022
Comparative Efficacy and Safety of 11 Drugs as Therapies for Adults With Neuropathic Pain After Spinal Cord Injury: A Bayesian Network Analysis Based on 20 Randomized Controlled Trials
InconclusivoMetanálise ClínicaDor Dor — Neuropatia Periférica Dor — Polineuropatia Inflamatória+1
2022
Correlates of treatment engagement and client outcomes: results of a randomised controlled trial of nabiximols for the treatment of cannabis use disorder
FavorávelEnsaio Clínico Duplo-CegoDor Dependência Química Dependência — Cannabis Tetraidrocanabinol (THC)THC:CBD Farmacêutico+3
2022
Could Palmitoylethanolamide Be an Effective Treatment for Long-COVID-19? Hypothesis and Insights in Potential Mechanisms of Action and Clinical Applications
FavorávelMetanáliseDor Inflamação Ansiedade Anandamida (AEA)Palmitoiletanolamida (PEA)+16
2022
Cutaneous Squamous Cell Carcinoma and Lichen Simplex Chronicus Successfully Treated with Topical Cannabinoid Oil: A Case Report and Summary of Cannabinoids in Dermatology
FavorávelMetanáliseCâncer Inflamação Ansiedade Anandamida (AEA)Endocanabinoide (não especificado)+24
2022
Does Cannabidiol Have a Benefit as a Supportive Care Drug in Cancer?
FavorávelMetanáliseDor Câncer Efeitos Adversos da Cannabis Anandamida (AEA)Endocanabinoide (não especificado)+19
2022
E-cigarette vaping associated acute lung injury (EVALI): state of science and future research needs
DesfavorávelMetanáliseCâncer Ansiedade Doenças Cardiovasculares (DCV)+16
2022
Effect of Medical Marijuana Card Ownership on Pain, Insomnia, and Affective Disorder Symptoms in Adults: A Randomized Clinical Trial
InconclusivoEnsaio ClínicoDor Dependência — Cannabis Ansiedade+4
2022
Effectiveness and Tolerability of Dronabinol Use in Patients with Chronic Pain: A Retrospective Analysis of 12-Week Open-Label Real-World Data Provided by the German Pain e-Registry
FavorávelMetanáliseDor Dor — Crônica Qualidade de Vida Tetraidrocanabinol (THC)THC Farmacêutico
2022
Efficiency of Inhaled Cannabidiol in Cannabis Use Disorder: The Pilot Study Cannavap
FavorávelMetanáliseDependência Química Câncer Inflamação THC Farmacêutico THC:CBD Farmacêutico+11
2022
Evaluating the impact of cannabinoids on sleep health and pain in patients with chronic neuropathic pain: a systematic review and meta-analysis of randomized controlled trials
FavorávelMetanálise ClínicaDor Dor — Crônica
2022
Evidence-based management of multiple sclerosis spasticity with nabiximols oromucosal spray in clinical practice: a 10-year recap
FavorávelMetanálise ClínicaDor Dor — Crônica Disfunção Cognitiva Tetraidrocanabinol (THC)THC:CBD Farmacêutico+1
2022
Geraniol enhances inhibitory inputs to the paraventricular thalamic nucleus and induces sedation in mice
FavorávelEstudo em AnimaisEpilepsia
2022
Higher Risk, Higher Reward? Self‐Reported Effects of Real‐World Cannabis Use in Parkinson's Disease
FavorávelMetanáliseDor Ansiedade Dor — Crônica+2
2022
Implications of the endocannabinoid system and the therapeutic action of cannabinoids in autism spectrum disorder: A literature review
FavorávelMetanáliseAnsiedade Disfunção Cognitiva Transtornos de Comportamento+1
2022
In the weeds: a retrospective study of patient interest in and experience with cannabis at a cancer center
FavorávelMetanáliseDor Câncer Ansiedade+14
2022
Integration of Cannabis Extract Tetrahydrocannabinol:Cannabidiol in an Interdisciplinary Therapy Setting: A Case of Chronic Multilocular Pain Disorder
FavorávelMetanáliseDor Câncer Inflamação Tetraidrocanabinol (THC)+10
2022
Is There a Place for Medicinal Cannabis in Treating Patients with Sleep Disorders? What We Know so Far
FavorávelMetanálise ClínicaApneia do Sono Síndrome das Pernas Inquietas Transtorno Comportamental do Sono REM Tetraidrocanabinol (THC)THC Farmacêutico+3
2022
Long-term observational studies with cannabis-based medicines for chronic non-cancer pain: A systematic review and meta-analysis of effectiveness and safety
FavorávelMetanáliseDor Ansiedade Dor — Crônica Hidrolase de Amidas de Ácidos Graxos (FAAH)THC Farmacêutico+5
2022
Mechanisms of Cannabidiol (CBD) in Cancer Treatment: A Review
FavorávelMetanáliseDor Câncer Inflamação Tetraidrocanabinol (THC)Endocanabinoide (não especificado)+13
2022
Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications
FavorávelMetanálise ClínicaDependência — Cannabis Ansiedade Depressão Tetraidrocanabinol (THC)THC Farmacêutico+17
2022
Medical cannabis and cannabinoids for impaired sleep: a systematic review and meta-analysis of randomized clinical trials
FavorávelMetanálise ClínicaDor Dor — Crônica
2022
Medical Marijuana Efficacy: A Survey
FavorávelMetanáliseDor Inflamação Ansiedade+3
2022
Medicinal cannabis improves sleep in adults with insomnia: a randomised double-blind placebo-controlled crossover study
FavorávelEnsaio Clínico Duplo-CegoTetraidrocanabinol (THC)THC:CBD Farmacêutico
2022
Mood, sleep and pain comorbidity outcomes in cannabis dependent patients: Findings from a nabiximols versus placebo randomised controlled trial
FavorávelEnsaio Clínico Duplo-CegoDor Dependência Química Efeitos Adversos da Cannabis Tetraidrocanabinol (THC)THC:CBD Farmacêutico+2
2022
Orchestration of the circadian clock and its association with Alzheimer's disease: Role of endocannabinoid signaling
FavorávelMetanáliseInflamação Doenças Neurodegenerativas Doença de Alzheimer Endocanabinoide (não especificado)
2022
Parkinson’s Disease and Dementia with Lewy Bodies, Patients Under Treatment with Standardized Extracts Enriched in Cannabidiol and Cannabigerol: Descriptive Observations in Preparation for a Phase 2a Clinical Trial
FavorávelMetanáliseDor Ansiedade Psicose Tetraidrocanabinol (THC)Canabigerol (CBG)+3
2022
Pentadecanoylcarnitine is a newly discovered endocannabinoid with pleiotropic activities relevant to supporting physical and mental health
FavorávelEstudo em AnimaisDor Inflamação Ansiedade Ácido Pentadecanoico (C15:0)Pentadecanoilcarnitina (PDC)+2
2022
Pilot clinical and pharmacokinetic study of Δ9-Tetrahydrocannabinol (THC)/Cannabidiol (CBD) nanoparticle oro-buccal spray in patients with advanced cancer experiencing uncontrolled pain
FavorávelEnsaio ClínicoDor Câncer Dor — Crônica Canabinol (CBN)Ácido Canabidiólico (CBD-a)+6
2022
Predictors of pain reduction among fibromyalgia patients using medical cannabis: a long-term prospective cohort study
FavorávelEnsaio ClínicoDor Ansiedade Dor — Crônica+2
2022
Pregnant People's Perspectives On Cannabis Use During Pregnancy: A Systematic Review and Integrative Mixed-Methods Research Synthesis
FavorávelMetanáliseDor Dependência Química Efeitos Adversos da Cannabis+7
2022
Prevalence and correlates of cannabis use disorder among Australians using cannabis products to treat a medical condition
DesfavorávelMetanáliseDor Dependência Química Câncer Tetraidrocanabinol (THC)+12
2022
Prevalence and self-reported reasons of cannabis use for medical purposes in USA and Canada
FavorávelMetanáliseDor Dor — Crônica Depressão+5
2022
Randomized controlled trials on the use of cannabis-based medicines in movement disorders: a systematic review
FavorávelMetanálise ClínicaAnsiedade Doença de Parkinson Doença de Huntington THC Farmacêutico CBD Farmacêutico+5
2022
Recreational cannabis legalizations associated with reductions in prescription drug utilization among Medicaid enrollees
FavorávelMetanáliseDor Ansiedade Dor — Crônica+3
2022
Role of Cannabinoids in Various Diseases: A Review
FavorávelMetanáliseDor Inflamação Dor — Crônica Endocanabinoide (não especificado)+9
2022
Sleep time differs among people who co-use cocaine and cannabis compared to people who only use cocaine
DesfavorávelEnsaio ClínicoDependência Química Efeitos Adversos da Cannabis Dependência — Cocaína
2022
Terpene-Enriched CBD oil for treating autism-derived symptoms unresponsive to pure CBD: Case report
FavorávelMetanáliseInflamação Ansiedade Depressão Anandamida (AEA)Hidrolase de Amidas de Ácidos Graxos (FAAH)+5
2022
The Effect of Cannabidiol for Restless Legs Syndrome/Willis-Ekbom Disease in Parkinson's Disease Patients with REM Sleep Behavior Disorder: A Post Hoc Exploratory Analysis of Phase 2/3 Clinical Trial
InconclusivoEnsaio Clínico Duplo-CegoDoença de Parkinson Apneia do Sono Síndrome das Pernas Inquietas
2022
The Effect of Oleoylethanolamide (OEA) Add-On Treatment on Inflammatory, Oxidative Stress, Lipid, and Biochemical Parameters in the Acute Ischemic Stroke Patients: Randomized Double-Blind Placebo-Controlled Study
FavorávelEnsaio Clínico Duplo-CegoDor Inflamação Ansiedade Anandamida (AEA)Hidrolase de Amidas de Ácidos Graxos (FAAH)+7
2022
The Effectiveness and Safety of Pharmaceutical-Grade Cannabidiol in the Treatment of Mastocytosis-Associated Pain: A Pilot Study
FavorávelEnsaio ClínicoDor Ansiedade Dor — Crônica+3
2022
The Effects of Cannabinoids on Sleep
InconclusivoMetanálise
2022
The intersection between integrative medicine and neuropathic pain: A case report
FavorávelMetanáliseDor Ansiedade Dor — Crônica Medicina Mente-Corpo Acupuntura (MTC)+2
2022
The Medicinal Natural Products of Cannabis sativa Linn.: A Review
FavorávelMetanáliseCâncer Inflamação Ansiedade Canabinoide Sintético (não especificado)THC Farmacêutico+26
2022
Tonic endocannabinoid signaling supports sleep through development in both sexes
FavorávelEstudo em AnimaisAnandamida (AEA)Endocanabinoide (não especificado)+2
2022
Topical Cannabidiol (CBD) After Total Knee Arthroplasty Does Not Decrease Pain or Opioid Use: A Prospective Randomized Double-Blinded Placebo-Controlled Trial
DesfavorávelEnsaio Clínico Duplo-CegoDor Dependência Química Dependência — Opioides+1
2022
Updates in the use of cannabis for insomnia
InconclusivoMetanáliseSíndrome das Pernas Inquietas
2021
A latent class analysis of cannabis use products in a general population sample of adolescents and their association with paranoia, hallucinations, cognitive disorganisation and grandiosity
DesfavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Ansiedade Psicose
2021
A pilot randomized clinical trial of Brief Behavioral Treatment for Insomnia to reduce problematic cannabis use among trauma-exposed young adults
FavorávelEnsaio ClínicoDependência Química Dependência — Cannabis TEPT
2021
A Review of the Potential Use of Pinene and Linalool as Terpene-Based Medicines for Brain Health: Discovering Novel Therapeutics in the Flavours and Fragrances of Cannabis
FavorávelMetanáliseInflamação Ansiedade Depressão+5
2021
A scoping review of the use of cannabidiol in psychiatric disorders
FavorávelMetanálise ClínicaDependência — Cannabis Ansiedade Psicose+4
2021
A Survey of Cannabis Use in a Large US-Based Cohort of People with Multiple Sclerosis
InconclusivoMetanáliseDor Ansiedade Dor — Crônica+1
2021
Adjunctive Management of Opioid Withdrawal with the Nonopioid Medication Cannabidiol
FavorávelMetanáliseDor Dependência Química Inflamação+7
2021
Approved cannabinoids for medical purposes - Comparative systematic review and meta-analysis for sleep and appetite
InconclusivoMetanálise ClínicaEfeitos Adversos da Cannabis Anorexia (perda de apetite)THC Farmacêutico CBD Farmacêutico
2021
Assessments and Interventions for Sleep Disorders in Infants With or at High Risk for Cerebral Palsy: A Systematic Review
InconclusivoMetanáliseParalisia Cerebral THC Farmacêutico CBD Farmacêutico
2021
Cancer patient's attitudes of using medicinal cannabis for sleep
FavorávelMetanáliseCâncer
2021
Cannabidiol (CBD) oil toxicity mimicking extraglandular complications of Sjögren’s syndrome
FavorávelMetanáliseEfeitos Adversos da Cannabis Doenças Cardiovasculares (DCV)Hipertensão Arterial+2
2021
Cannabidiol and Neurodevelopmental Disorders in Children
FavorávelMetanáliseInflamação Ansiedade Depressão Anandamida (AEA)2-Araquidonoilglicerol (2-AG)+17
2021
Cannabidiol and the corticoraphe circuit in post-traumatic stress disorder
FavorávelMetanáliseAnsiedade TEPT Anandamida (AEA)
2021
Cannabidiol for Rapid Eye Movement Sleep Behavior Disorder
FavorávelEnsaio Clínico Duplo-CegoDoença de Parkinson Transtorno Comportamental do Sono REM
2021
Cannabidiol for the treatment of crack-cocaine craving: an exploratory double-blind study
InconclusivoEnsaio Clínico Duplo-CegoDependência Química Inflamação Dependência — Cannabis Anandamida (AEA)+8
2021
Cannabidiol Use, Substitution for Medications, and Perceptions of Effectiveness in Women with Chronic Pelvic Pain
FavorávelMetanáliseDor Efeitos Adversos da Cannabis Ansiedade+8
2021
Cannabinoid control of hippocampal functions: the where matters
FavorávelMetanáliseInflamação Epilepsia Disfunção Cognitiva Anandamida (AEA)Endocanabinoide (não especificado)+6
2021
Cannabinoids and bladder symptoms in multiple sclerosis
FavorávelMetanáliseDor Ansiedade Dor — Crônica+4
2021
Cannabinoids for the treatment of dementia
InconclusivoMetanálise ClínicaDisfunção Cognitiva Doença de Alzheimer Demência Canabinoide Sintético (não especificado)THC Farmacêutico+2
2021
Cannabinol and Sleep: Separating Fact from Fiction
InconclusivoMetanáliseCanabinol (CBN)
2021
Cannabis consumption in young adults with cancer: descriptive study
FavorávelMetanáliseDor Câncer Ansiedade+3
2021
Cannabis sativa Linnaeus as traditional phytomedicine by folk medicine practitioners of Bangladesh
FavorávelMetanáliseCâncer Doenças Cardiovasculares (DCV)Artrite+4
2021
Cannabis Use among Cancer Survivors amid the COVID-19 Pandemic: Results from the COVID-19 Cannabis Health Study
InconclusivoEnsaio ClínicoCâncer Epilepsia Náusea e Vômito+3
2021
Cannabis Use among Older Persons with Arthritis, Cancer and Multiple Sclerosis: Are We Comparing Apples and Oranges?
FavorávelEnsaio ClínicoCâncer Esclerose Múltipla Artrite+1
2021
Clinical outcome data of first cohort of chronic pain patients treated with cannabis-based sublingual oils in the United Kingdom - analysis from the UK Medical Cannabis Registry
FavorávelMetanáliseDor Dor — Crônica
2021
Contribution of the Adenosine 2A Receptor to Behavioral Effects of Tetrahydrocannabinol, Cannabidiol and PECS-101
DesfavorávelEstudo em AnimaisDor Inflamação Efeitos Adversos da Cannabis+5
2021
Could Cannabidiol Be a Treatment for Coronavirus Disease-19-Related Anxiety Disorders?
FavorávelMetanáliseAnsiedade Depressão TEPT+1
2021
Developing a real-world evidence base for prescribed cannabis in the United Kingdom: preliminary findings from Project Twenty21
FavorávelMetanáliseDor Ansiedade Dor — Crônica+1
2021
Disposition of cannabinoids and their metabolites in serum, oral fluid, sweat patch and urine from healthy individuals treated with pharmaceutical preparations of medical cannabis
FavorávelEstudo LaboratorialPerda de Apetite Ácido Canabidiólico (CBD-a)Ácido Tetraidrocanabinólico (THC-a)
2021
Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals
FavorávelMetanálise
2021
Effects of Cannabis Consumption on Sleep
InconclusivoMetanálise
2021
Effects on the Post-translational Modification of H3K4Me3, H3K9ac, H3K9Me2, H3K27Me3, and H3K36Me2 Levels in Cerebral Cortex, Hypothalamus and Pons of Rats after a Systemic Administration of Cannabidiol: A Preliminary Study
InconclusivoEstudo Laboratorial
2021
Essential Oil from the Leaves of Chromolaena odorata, and Sesquiterpene Caryophyllene Oxide Induce Sedative Activity in Mice
InconclusivoEstudo em AnimaisOutros Compostos Relacionados
2021
Evaluation of Patient Reported Safety and Efficacy of Cannabis From a Survey of Medical Cannabis Patients in Canada
FavorávelMetanáliseDor Dor — Crônica Artrite+3
2021
Exploring the Relationship Between ADHD Symptoms and Daily Cannabis Consequences in Emerging Adulthood: The Role of Cannabis Motives
DesfavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Transtornos de Comportamento TDA e TDAH
2021
Exploring the Use of Medical Marijuana for Supportive Care of Oncology Patients
FavorávelMetanáliseDor Câncer Náusea e Vômito+1
2021
Healing of a Chronic Pressure Injury in a Patient Treated With Medical Cannabis for Pain and Sleep Improvement: A Case Report
FavorávelMetanáliseDor Dor — Crônica Cicatrização+1
2021
Human Laboratory Models of Cannabis Use: Applications for Clinical and Translational Psychiatry Research
FavorávelMetanáliseDor Dependência Química Câncer+16
2021
Improved Bioavailability with Dry Powder Cannabidiol Inhalation: A Phase 1 Clinical Study
FavorávelEnsaio ClínicoDor Ansiedade Dor — Crônica CBD Farmacêutico+3
2021
In vivo brain levels of acetylcholine and 5-hydroxytryptamine after oleoylethanolamide or palmitoylethanolamide administrations are mediated by PPARα engagement
FavorávelEstudo em AnimaisPalmitoiletanolamida (PEA)Virodamina (O-AEA)
2021
Knowledge and attitudes of Italian medical oncologists and palliative care physicians toward medical use of cannabis in cancer care: a national survey
FavorávelMetanáliseDor Câncer Náusea e Vômito+2
2021
Marijuana use and sleep quality during pregnancy
InconclusivoEnsaio ClínicoGestação
2021
Medical cannabinoids for treatment of neuropsychiatric symptoms in dementia: a systematic review
FavorávelMetanáliseDisfunção Cognitiva Doenças Neurodegenerativas Doença de Alzheimer THC Farmacêutico THC:CBD Farmacêutico+5
2021
Medical Cannabis in Oncology: a Valuable Unappreciated Remedy or an Undesirable Risk?
InconclusivoMetanáliseDor Câncer Ansiedade+5
2021
Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials
InconclusivoMetanálise ClínicaDor Dor — Crônica Dor — Oncológica
2021
Medical Cannabis Use Among Older Adults in Canada: Self-Reported Data on Types and Amount Used, and Perceived Effects
FavorávelMetanáliseDor Câncer Ansiedade+5
2021
Medicinal applications of cannabis/cannabinoids
InconclusivoMetanáliseDor Epilepsia CBD Farmacêutico
2021
Modulation of Noradrenergic and Serotonergic Systems by Cannabinoids: Electrophysiological, Neurochemical and Behavioral Evidence
FavorávelMetanáliseDor Ansiedade Dor — Crônica+1
2021
Natural Cannabinoids as Templates for Sleep Disturbances Treatments
FavorávelMetanálise
2021
No pain, all gain? Interim analyses from a longitudinal, observational study examining the impact of medical cannabis treatment on chronic pain and related symptoms
FavorávelMetanáliseDor Ansiedade Dor — Crônica
2021
Opioid-sparing effects of medical cannabis or cannabinoids for chronic pain: a systematic review and meta-analysis of randomised and observational studies
InconclusivoMetanáliseDor Dor — Crônica Dependência — Opioides+3
2021
Pain Profiles among Young Adult Cannabis Users: An Analysis of Antecedent Factors and Distal Outcomes
FavorávelMetanáliseDor Dor — Crônica Dor — Aguda
2021
Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study
FavorávelEnsaio Clínico Duplo-CegoPalmitoiletanolamida (PEA)
2021
Perspectives of pediatric oncologists and palliative care physicians on the therapeutic use of cannabis in children with cancer
FavorávelMetanáliseDor Câncer Dor — Crônica+7
2021
Potential Role of Cannabidiol on Sports Recovery: A Narrative Review
FavorávelMetanáliseDor Ansiedade Disfunção Cognitiva+2
2021
Prevalence of Cannabidiol Use in Patients With Spine Complaints: Results of an Anonymous Survey
FavorávelMetanáliseDor Ansiedade Dor — Crônica+2
2021
Prospects for the Use of Cannabinoids in Psychiatric Disorders
InconclusivoMetanáliseAnsiedade Depressão Demência
2021
Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems
FavorávelMetanáliseAnsiedade
2021
Reasons for using cannabidiol: a cross-sectional study of French cannabidiol users
InconclusivoMetanáliseAnsiedade Estresse Oxidativo
2021
Sedative effects of l-menthol, d-camphor, phenylethyl alcohol, and geraniol
FavorávelEstudo em AnimaisAnsiedade
2021
Seizure frequency, quality of life, behavior, cognition, and sleep in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol
FavorávelEnsaio ClínicoEpilepsia Transtornos de Comportamento CBD Farmacêutico
2021
Sleep-wake cycle disturbances and NeuN-altered expression in adult rats after cannabidiol treatments during adolescence
DesfavorávelEnsaio Clínico
2021
Survey of Patients Employing Cannabigerol-Predominant Cannabis Preparations: Perceived Medical Effects, Adverse Events, and Withdrawal Symptoms
FavorávelMetanáliseDor Ansiedade Dor — Crônica Canabigerol (CBG)+1
2021
The Effect of Cannabinoids on the Brain's Circadian Clock
InconclusivoMetanálise
2021
The effect of daily aerobic cycling exercise on sleep quality during inpatient cannabis withdrawal: A randomised controlled trial
FavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Dependência — Cannabis
2021
The Effect of Medical Cannabis on Pain Level and Quality of Sleep among Rheumatology Clinic Outpatients
FavorávelMetanáliseDor Inflamação Efeitos Adversos da Cannabis+8
2021
The Effectiveness of Cannabis and Cannabis Derivatives in Treating Lower Back Pain in the Aged Population: A Systematic Review
InconclusivoMetanáliseDor Ansiedade Dor — Crônica THC Farmacêutico CBD Farmacêutico+2
2021
The Use of Cannabinoids for Insomnia in Daily Life: Naturalistic Study
FavorávelMetanálise
2021
Treating Insomnia Symptoms with Medicinal Cannabis: A Randomized, Cross-Over Trial of the Efficacy of a Cannabinoid Medicine Compared with Placebo
FavorávelEnsaio Clínico Duplo-Cego
2021
Universal and Selective Interventions to Prevent Poor Mental Health Outcomes in Young People: Systematic Review and Meta-analysis
FavorávelMetanáliseDependência Química Dependência — Cannabis Ansiedade+7
2020
A Literature Analysis on Medicinal Use and Research of Cannabis in the Meiji Era of Japan
FavorávelMetanáliseDor Dor — Crônica Doenças Neurodegenerativas+3
2020
A Little Dab Will Do: A Case of Cannabis-Induced Psychosis
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Dependência — Cannabis Ansiedade+4
2020
Acute effects of cannabinoids on symptoms of obsessive-compulsive disorder: A human laboratory study
DesfavorávelEnsaio Clínico Duplo-CegoAnsiedade Depressão TOC Tetraidrocanabinol (THC)Endocanabinoide (não especificado)
2020
Adult attention-deficit hyperactivity disorder and clinical correlates of delayed sleep phase disorder
DesfavorávelEnsaio ClínicoTranstornos de Comportamento TDA e TDAH
2020
Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) for chronic insomnia disorder ('CANSLEEP' trial): protocol for a randomised, placebo-controlled, double-blinded, proof-of-concept trial
DesfavorávelEnsaio Clínico Duplo-Cego
2020
Cannabidiol and Sports Performance: a Narrative Review of Relevant Evidence and Recommendations for Future Research
FavorávelMetanáliseDor Inflamação Ansiedade+6
2020
Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies
InconclusivoMetanálise
2020
Cannabinoids in the Treatment of Insomnia Disorder: A Systematic Review and Meta-Analysis
FavorávelMetanálise Clínica
2020
Cannabinoids, Endocannabinoids and Sleep
InconclusivoMetanáliseAnandamida (AEA)2-Araquidonoilglicerol (2-AG)+2
2020
Cannabis use is associated with greater total sleep time in middle-aged and older adults with and without HIV: A preliminary report utilizing digital health technologies
FavorávelMetanáliseHIV/AIDS
2020
Effects of Hemp Extract on Markers of Wellness, Stress Resilience, Recovery and Clinical Biomarkers of Safety in Overweight, But Otherwise Healthy Subjects
FavorávelEnsaio Clínico Duplo-CegoDoenças Cardiovasculares (DCV)Estresse Oxidativo Obesidade+2
2020
Industrial Hemp (Cannabis sativa subsp. sativa) as an Emerging Source for Value-Added Functional Food Ingredients and Nutraceuticals
FavorávelMetanáliseCâncer Ansiedade Doenças Cardiovasculares (DCV)+6
2020
Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
FavorávelEnsaio Clínico Duplo-CegoDor Depressão Fibromialgia Canabigerol (CBG)Canabinol (CBN)+3
2020
Medical cannabis and insomnia in older adults with chronic pain: a cross-sectional study
InconclusivoMetanáliseDor Dor — Crônica
2020
Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review
FavorávelMetanáliseAnsiedade Depressão Psicose+3
2020
Medicinal Use of Cannabis in Children and Pregnant Women
FavorávelMetanáliseAnsiedade Dependência — Álcool Náusea e Vômito+5
2020
Non-Motor Symptoms in Parkinson's Disease are Reduced by Nabilone
FavorávelEnsaio Clínico Duplo-CegoDoenças Neurodegenerativas Doença de Parkinson Transtornos de Comportamento Endocanabinoide (não especificado)THC Farmacêutico
2020
Sleep and neurochemical modulation by cannabidiolic acid methyl ester in rats
FavorávelEstudo em AnimaisAnsiedade Depressão Náusea e Vômito Canabinoides Sintéticos HU-x Ácido Canabidiólico (CBD-a)
2020
Small bowel intussusception in marijuana users
DesfavorávelMetanáliseDor Efeitos Adversos da Cannabis Dor — Crônica+6
2020
The Endocannabinoid System May Modulate Sleep Disorders in Aging
InconclusivoMetanáliseAnsiedade Doenças Cardiovasculares (DCV)Depressão Anandamida (AEA)Endocanabinoide (não especificado)+13
2019
A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis
FavorávelEnsaio Clínico Duplo-CegoAnsiedade Depressão Palmitoiletanolamida (PEA)
2019
A Review on Studies of Marijuana for Alzheimer's Disease - Focusing on CBD, THC
FavorávelMetanáliseCâncer Inflamação Disfunção Cognitiva Canabigerol (CBG)Canabinol (CBN)+4
2019
A systematic review of cannabidiol dosing in clinical populations
FavorávelMetanálise ClínicaDor Dependência — Cannabis Ansiedade+14
2019
Acute effect of vaporized Cannabis on sleep and electrocortical activity
FavorávelEstudo em Animais
2019
Benefit of Tetrahydrocannabinol versus Cannabidiol for Common Palliative Care Symptoms
FavorávelMetanáliseDor Ansiedade Depressão+4
2019
Cannabidiol Adverse Effects and Toxicity
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Náusea e Vômito
2019
Cannabidiol in Anxiety and Sleep: A Large Case Series
FavorávelMetanáliseAnsiedade
2019
Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series
FavorávelMetanáliseAnsiedade Depressão Disfunção Cognitiva+3
2019
Cannabidiol partially blocks the sleepiness in hypocretin-deficient rats: Preliminary data
FavorávelEstudo em Animais
2019
Cannabis Expectancies for Sleep
FavorávelMetanálise
2019
Clinical Challenges in Patients with First Episode Psychosis and Cannabis Use: Mini-Review and a Case Study
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Dependência — Cannabis Ansiedade Canabinoide Sintético (não especificado)+7
2019
Naturally occurring compounds as pancreatic cancer therapeutic
FavorávelMetanáliseDor Câncer Dor — Oncológica+2
2019
Perceived Efficacy of Medical Cannabis in the Treatment of Co-Occurring Health-Related Quality of Life Symptoms
FavorávelMetanáliseDor Ansiedade Depressão
2019
Potential Adverse Drug Events and Drug–Drug Interactions with Medical and Consumer Cannabidiol (CBD) Use
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Infecções Bacterianas Caquexia
2019
Psychopathological symptoms associated with synthetic cannabinoid use: a comparison with natural cannabis
DesfavorávelMetanáliseEfeitos Adversos da Cannabis Dependência — Cannabis Ansiedade Canabinoide Sintético (não especificado)+5
2019
The use of cannabinoids for sleep: A critical review on clinical trials
FavorávelMetanáliseDor Dor — Crônica Esclerose Múltipla Tetraidrocanabinol (THC)+1
2019
Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
FavorávelMetanáliseAnsiedade Depressão Epilepsia+3
2019
Use of Cannabis to Relieve Pain and Promote Sleep by Customers at an Adult Use Dispensary
FavorávelMetanáliseDor Dor — Crônica
2019
Using recreational cannabis to treat insomnia: Evidence from over-the-counter sleep aid sales in Colorado
FavorávelMetanálise
2018
A Cross-Sectional Study of Cannabidiol Users
FavorávelMetanáliseDor Ansiedade Dor — Crônica+1
2018
A Systematic Review of the Efficacy of Cannabinoid Agonist Replacement Therapy for Cannabis Withdrawal Symptoms
FavorávelMetanálise ClínicaDependência Química Dependência — Cannabis Ansiedade Tetraidrocanabinol (THC)Canabinoide Sintético (não especificado)+4
2018
Abuse potential assessment of cannabidiol (CBD) in recreational polydrug users: A randomized, double-blind, controlled trial
FavorávelEnsaio Clínico Duplo-CegoEfeitos Adversos da Cannabis Epilepsia Disfunção Cognitiva THC Farmacêutico CBD Farmacêutico+5
2018
Cannabidiol inhibits priming-induced reinstatement of methamphetamine in REM sleep deprived rats
FavorávelEstudo em AnimaisDependência Química Dependência — Estimulantes
2018
Cannabinoid-mediated retinal rescue correlates with improved circadian parameters in retinal dystrophic rats.
FavorávelEstudo em AnimaisDoenças da Retina Canabinoides Sintéticos HU-x
2018
Characteristics and Patterns of Marijuana Use in Community-Dwelling Older Adults
FavorávelMetanáliseDor Ansiedade Depressão+1
2018
Endocannabinoid signalling: has it got rhythm?
FavorávelMetanáliseAnandamida (AEA)
2018
Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders
FavorávelEnsaio ClínicoDoença de Parkinson Paralisia Cerebral Tetraidrocanabinol (THC)
2018
The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial
FavorávelEnsaio Clínico Duplo-CegoDor Anorexia (perda de apetite)Dor — Oncológica THC Farmacêutico+4
2018
The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report.
FavorávelMetanáliseDor Ansiedade Dor — Crônica+7
2017
Cannabis Use in Palliative Oncology: A Review of the Evidence for Popular Indications
FavorávelMetanáliseDor Ansiedade Anorexia (perda de apetite)+2
2017
Cannabis, Cannabinoids, and Sleep: a Review of the Literature
FavorávelMetanáliseDor — Crônica Apneia do Sono Transtorno Comportamental do Sono REM THC Farmacêutico
2017
Efficacy of Silexan in Subthreshold Anxiety: Meta-Analysis of Randomised, Placebo-Controlled Trials
FavorávelMetanálise ClínicaAnsiedade Depressão
2017
Reductions in cannabis use are associated with improvements in anxiety, depression, and sleep quality, but not quality of life
FavorávelMetanálise ClínicaDependência Química Efeitos Adversos da Cannabis Dependência — Cannabis+3
2017
Smoked marijuana attenuates performance and mood disruptions during simulated night shift work.
FavorávelEnsaio Clínico Duplo-CegoTetraidrocanabinol (THC)
2017
Substitution Of Medical Cannabis For Pharmaceutical Agents For Pain, Anxiety, And Sleep
FavorávelMetanáliseDor Ansiedade
2016
Cannabinoids in Palliative Care: Systematic Review and Meta-Analysis of Efficacy, Tolerability and Safety
InconclusivoMetanálise ClínicaDor Câncer Náusea e Vômito+4
2016
Effectiveness Of Cannabidiol Oil For Pediatric Anxiety And Insomnia As Part Of Posttraumatic Stress Disorder: A Case Report
FavorávelMetanáliseAnsiedade TEPT
2016
Effects of zolpidem alone and in combination with nabilone on cannabis withdrawal and a laboratory model of relapse in cannabis users
FavorávelEnsaio ClínicoDependência Química Efeitos Adversos da Cannabis Dependência — Cannabis THC Farmacêutico+2
2016
Efficacy, Tolerability, and Safety of Cannabinoid Treatments in the Rheumatic Diseases: A Systematic Review of Randomized Controlled Trials
FavorávelMetanálise ClínicaDor Artrite Artrite — Reumatoide Canabinoide Sintético (não especificado)THC Farmacêutico+2
2016
Influence of Previous Failed Antispasticity Therapy on the Efficacy and Tolerability of THC:CBD Oromucosal Spray for Multiple Sclerosis Spasticity
FavorávelEnsaio ClínicoEsclerose Múltipla THC:CBD Farmacêutico
2016
Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol
InconclusivoEnsaio ClínicoObesidade Síndrome Metabólica
2016
Splendor In The Grass? A Pilot Study Assessing The Impact Of Medical Marijuana On Executive Function
FavorávelMetanáliseDepressão Dependência — Opioides Condições Geriátricas
2016
α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice Through GABAA-benzodiazepine Receptors
FavorávelEstudo em Animais
2015
Cannabinoids for Medical Use A Systematic Review and Meta-analysis
FavorávelMetanáliseDor Dor — Crônica Caquexia+2
2015
Cannabis withdrawal and sleep: A systematic review of human studies
InconclusivoMetanálise ClínicaDependência Química Dependência — Cannabis
2015
Efficacy of orally administered Silexan in patients with anxiety-related restlessness and disturbed sleep – A randomized, placebo-controlled trial
FavorávelEnsaio Clínico Duplo-CegoAnsiedade
2015
Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial
InconclusivoEnsaio Clínico Duplo-CegoDor Câncer Náusea e Vômito THC Farmacêutico+5
2015
MDMA, cannabis, and cocaine produce acute dissociative symptoms
DesfavorávelEnsaio ClínicoDependência Química Efeitos Adversos da Cannabis Ansiedade+7
2015
The Effects of Lithium Carbonate Supplemented with Nitrazepam on Sleep Disturbance during Cannabis Abstinence
FavorávelEnsaio Clínico Duplo-CegoDependência Química Efeitos Adversos da Cannabis Dependência — Cannabis
2015
Therapeutic potential of cannabinoids in counteracting chemotherapy-induced adverse effects: an exploratory review.
FavorávelMetanáliseDor Câncer Doenças Cardiovasculares (DCV)+9
2014
A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment
FavorávelEnsaio Clínico Duplo-CegoDor Dor — Neuropatia Periférica Tetraidrocanabinol (THC)THC:CBD Farmacêutico
2014
Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series.
FavorávelMetanáliseDoença de Parkinson Transtorno Comportamental do Sono REM
2014
How cannabis causes paranoia: using the intravenous administration of ∆9-tetrahydrocannabinol (THC) to identify key cognitive mechanisms leading to paranoia
DesfavorávelEnsaio Clínico Duplo-CegoEfeitos Adversos da Cannabis Dependência — Cannabis Ansiedade THC Farmacêutico+4
2014
Potential Effects of Cannabidiol as a Wake-Promoting Agent.
FavorávelMetanálise
2014
Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder
FavorávelEnsaio ClínicoDependência — Cannabis TEPT Tetraidrocanabinol (THC)
2013
Around‐the‐clock oral THC effects on sleep in male chronic daily cannabis smokers.
FavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Tetraidrocanabinol (THC)
2013
Characterization of Anxiolytic and Neuropharmacological Activities of Silexan
FavorávelEstudo em AnimaisAnsiedade
2013
Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats.
FavorávelEstudo em Animais
2012
A human laboratory study investigating the effects of quetiapine on marijuana withdrawal and relapse in daily marijuana smokers
DesfavorávelEnsaio Clínico Duplo-CegoDependência Química Efeitos Adversos da Cannabis Dependência — Cannabis+1
2012
An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics
FavorávelEnsaio ClínicoDor Câncer Ansiedade Endocanabinoide (não especificado)THC Farmacêutico+10
2012
Antidepressant activity of Litsea glaucescens essential oil: Identification of β-pinene and linalool as active principles
FavorávelEstudo LaboratorialDor Ansiedade Depressão Medicina Mente-Corpo+6
2012
Can oral fluid cannabinoid testing monitor medication compliance and/or cannabis smoking during oral THC and oromucosal Sativex administration?
FavorávelEnsaio ClínicoDor Efeitos Adversos da Cannabis Dependência — Cannabis THC:CBD Farmacêutico Canabinol (CBN)+9
2012
Multiple sclerosis and extract of cannabis: results of the MUSEC trial
FavorávelEnsaio Clínico Duplo-CegoDor Esclerose Múltipla
2012
Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial
FavorávelEnsaio Clínico Duplo-CegoDor Câncer Dor — Crônica THC:CBD Farmacêutico+2
2011
A placebo-controlled, parallel-group, randomized withdrawal study of subjects with symptoms of spasticity due to multiple sclerosis who are receiving long-term Sativex® (nabiximols)
FavorávelEnsaio ClínicoDor Ansiedade Dor — Crônica Anandamida (AEA)Endocanabinoide (não especificado)+8
2011
Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial
FavorávelEnsaio Clínico Duplo-CegoDor Câncer Inflamação THC Farmacêutico+9
2011
Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds
FavorávelEstudo em Animais
2011
Sleep disturbance and the effects of extended-release zolpidem during cannabis withdrawal
DesfavorávelEnsaio ClínicoEfeitos Adversos da Cannabis Dependência — Cannabis Dependência — Nicotina
2010
Silexan, an Orally Administered Lavandula Oil Preparation, Is Effective in the Treatment of 'Subsyndromal' Anxiety Disorder: A Randomized, Double-Blind, Placebo Controlled Trial
FavorávelEnsaio Clínico Duplo-CegoAnsiedade
2009
The Effects of Nabilone on Sleep in Fibromyalgia: Results of a Randomized Controlled Trial.
FavorávelEnsaio Clínico Duplo-CegoFibromialgia
2008
Inhaled linalool-induced sedation in mice.
FavorávelEstudo em AnimaisAnsiedade Epilepsia
2008
Open-Label, Add-on Study of Tetrahydrocannabinol for Chronic Nonmalignant Pain
FavorávelEnsaio ClínicoDor Dor — Crônica Perda de Apetite Tetraidrocanabinol (THC)+2
2008
The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent
FavorávelEstudo em Animais
2007
Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine
FavorávelEnsaio ClínicoDor Esclerose Múltipla Dor — Neuropatia Periférica THC:CBD Farmacêutico+3
2005
Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis
FavorávelEnsaio Clínico Duplo-CegoDor Esclerose Múltipla Dor — Síndrome da Dor Central Tetraidrocanabinol (THC)THC:CBD Farmacêutico
2005
Survey of Australians using cannabis for medical purposes
FavorávelMetanáliseDor Dor — Crônica Depressão+3
2003
Behavioral and subjective effects of marijuana following partial sleep deprivation
InconclusivoEnsaio ClínicoEfeitos Adversos da Cannabis
2003
Effect of D-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults
FavorávelEnsaio Clínico Duplo-CegoTetraidrocanabinol (THC)
2002
Central Effects of Citral, Myrcene and Limonene, Constituents of Essential Oil Chemotypes From Lippia Alba (Mill.) n.e. Brown
FavorávelEstudo em AnimaisAnsiedade Medicina Mente-Corpo
1998
Anandamida modulates sleep and memory in rats.
FavorávelEstudo em AnimaisAnandamida (AEA)Outros Compostos Relacionados
1982
The effect of chronically administered delta-9-tetrahydrocannabinol upon the polygraphically monitored sleep of normal volunteers.
FavorávelEnsaio Clínico Duplo-Cego
1981
Hypnotic And Antiepileptic Effects Of Cannabidiol
FavorávelMetanálise ClínicaEpilepsia Epilepsia — Síndrome de Dravet Epilepsia — Lennox-Gastaut
1978
Toward drugs derived from Cannabis
FavorávelMetanáliseDor Inflamação Dor — Crônica Tetraidrocanabinol (THC)THC Farmacêutico+7
1977
Hypnoticlike effects of cannabidiol in the rat
FavorávelEstudo em Animais
1976
Effects of marijuana extract and tetrahydrocannabinol on electroencephalographic sleep patterns
FavorávelEnsaio ClínicoCanabinol (CBN)
1975
Effect of chronic marijuana administration of stages of primate sleep-wakefulness.
FavorávelEstudo em AnimaisTetraidrocanabinol (THC)
1975
Effects of high dosage delta-9-tetrahydrocannabinol on sleep patterns in man.
FavorávelEnsaio Clínico
1973
Δ9-Tetrahydrocannabinol and the sleep-wakefulness cycle in rabbits
FavorávelEstudo em AnimaisTetraidrocanabinol (THC)
1918
Dispensatory of the United States, 20th ed. (1918)
FavorávelMetanáliseDor Ansiedade Dor — Crônica+4
1890
Cannabis Indica
FavorávelMetanáliseDor Dor — Crônica Doença de Alzheimer+6
1843
Observations on the medicinal properties of the Cannabis Sativa of India
FavorávelMetanáliseDor Câncer Depressão+10
1839
On the Preparations of the Indian Hemp, or Gunjah (Cannabis Indica), Their Effects on the Animal System in Health, and Their Utility in the Treatment of Tetanus and Other Convulsive Diseases
FavorávelMetanáliseEpilepsia Artrite Anorexia (perda de apetite)+7

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Canabinoides e compostos

Tetraidrocanabinol (THC) 37 THC Farmacêutico 35 THC:CBD Farmacêutico 26 Anandamida (AEA) 25 Endocanabinoide (não especificado) 21 CBD Farmacêutico 20 2-Araquidonoilglicerol (2-AG) 16 Canabinol (CBN) 15

Sistemas do corpo

Sistema Nervoso 131 Saúde Mental e Emocional 78 Sistema Esquelético 8 Sistema Muscular 7 Sistema Reprodutor 6 Sistema Respiratório 4

Perguntas frequentes

Quantos estudos sobre insônia e distúrbios do sono estão indexados no acervo?

São 296 estudos, publicados entre 1839 e 2024. O acervo inteiro tem 7.640 registros.

Que tipos de estudo predominam?

Metanálise: 147 · Ensaio Clínico: 46 · Ensaio Clínico Duplo-Cego: 45 · Metanálise Clínica: 29 · Estudo em Animais: 24 · Estudo Laboratorial: 5. A classificação segue o desenho declarado na fonte.

O que significa a classificação de resultado?

É uma leitura automatizada da conclusão de cada estudo, em três direções — favorável, inconclusivo e desfavorável. Aqui são 216 favoráveis, 46 inconclusivos e 34 desfavoráveis. Serve para navegar o acervo, não para concluir nada clinicamente: a conclusão válida é a do artigo original.

Como citar esta página

ABNT

CANNABIS INDICA. Insônia e Distúrbios do Sono — estudos científicos sobre cannabis. 2026. Disponível em: https://cannabisindica.com.br/condicao/insonia-e-disturbios-do-sono/. Acesso em: 13 set. 2026.

APA

Cannabis Indica. (2026). Insônia e Distúrbios do Sono — estudos científicos sobre cannabis. https://cannabisindica.com.br/condicao/insonia-e-disturbios-do-sono/

Esta página é um índice de acesso. Ao usar um estudo como evidência, cite o artigo original — o link de cada registro leva à fonte.